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University of Kansas Cancer Center
University of Kansas Cancer Center  :  Leadership

Yvonne Wan, PhD


Y WanProgram Leader, Metabolic & Inflammatory Risk Factors for Cancer Research Program
ywan@kumc.edu

Yvonne Wan, PhD was named program leader of the Metabolic & Inflammatory Risk Factors for Cancer Research Program in 2007. The Metabolic & Inflammatory Risk Factors for Cancer Research Program is undergoing strategic planning to better grow the program and foster collaboration.      

The primary focus of Dr. Wan’s research for the past decade has been retinoic acid and its receptors.  She has demonstrated that retinoic and its receptor play a pivotal role in growth, differentiation, apoptosis, proliferation, and carcinogenesis. 

Background

Dr. Wan received a Bachelor of Science degree from Taipei Medical College in Taipei, Taiwan.  She went on to complete her MS and PhD degrees in Pathology from Hahnemann University School of Medicine in Philadelphia. 

Dr. Wan joined the University of Kansas Medical Center in 2003 as a Professor in the Department of Pharmacology, Toxicology & Therapeutics.    

The primary focus of Dr. Wan’s research for the past decade has been retinoic acid and its receptors.  She has demonstrated that retinoic and its receptor play a pivotal role in growth, differentiation, apoptosis, proliferation, and carcinogenesis. 

Membership Organizations

  • Society of Toxicology
  • Research Society of Alcoholism
  • The Endocrine Society
  • American Association for Cancer Research
  • American Society of Microbiology, Division of Molecular Biology
  • American Association for the Advancement of Science
  • Society of Chinese Bioscientists in America

Recent Publications

  1. Luo H, Poland R, Lin K-M, Wan Y-J. Genetic polymorphism of CYP2C19 in Mexican Americans: a cross-ethnic comparative study, Clinical Pharmacology and Therapeutics, 80: 33-40, 2006.
  2. Dai G, Chou N, He L, Gyamfi M, Mendy AJ, Wan Y-J. Gender difference of acetaminophen-induced hepatotoxicity in mouse. Toxicological Sciences, 92: 33-41, 2006.
  3. Wan Y-J, Mostafa ZB. Inhibition of carrageenan-induced cutaneous inflammation by PPAR agonists is dependent on hepatocyte-specific retinoids x receptor alpha. PPAR Journal, Vol 2006, Article ID 96341,1-6, 2006.
  4. Gyamfi M, Wan Y-J. The effect of ethanol, ethanol metabolizing enzyme inhibitors, and vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte. Hepatology Research, 35: 53-61, 2006.
  5. Wang K, Mendy AL, Dai G, Luo H, He L, Wan Y-J. Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma Cells. Toxicological Sciences, 92: 51-60, 2006.
  6. Nakamoto K, Wang S, Jenison RD, Guo G, Klaassen CD, Wan Y-J, Zhong X. Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. Biomedical Central Genentics, 7: 29, 2006.
  7. Gyamfi M, Dai G, Kocsis M, He L, Mendy A, Wan Y-J. The role of retinoid X receptor alpha (RXRα) in regulating alcohol detoxification mediated by phase I and phase II enzymes. Journal of Pharmacology and Experimental Therapeutics. 319: 360-368, 2006.
  8. Luo H, Wan Y-J. Polymorphism of genes encoding phase I enzymes in Mexican Americans- An ethnic comparison study. Current Pharmacogenomics, 4: 345-353, 2006.
  9. Nakamoto K, Kidd JR, Luo H, Jenison RD, Klaassen CD, Wan Y-J, Zhong X. Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenomics and Genetics, In press, 2007.
  10. Wortham M, Czerwinskin M, He L, Parkinson A, Wan Y-J. Expression of CAR, HNFα, and POR genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human. Drug Metabolism and Disposition. In press, 2007